Evaluating totipotency using criteria of increasing stringency

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description Publication keyboard_double_arrow_right Article , Journal 01 Jan 2021 Belgium Publisher: Springer Science and Business Media LLC Journal: Nature Cell Biology , volume 23 , pages 49 - 60 ( issn: 1465-7392 , eissn: 1476-4679 , Copyright policy )

Authors: Adrian Janiszewski; Vincent Pasque; John P. Schell; John P. Schell; Pankaj Kumar; Pankaj Kumar; Tine Pardon; +17 Authors

Adrian Janiszewski; Vincent Pasque; John P. Schell; John P. Schell; Pankaj Kumar; Pankaj Kumar; Tine Pardon; Andrea Jurisicova; Andrea Jurisicova; Alexander Murray; Tatsuya Yamakawa; Natalie De Geest; Isidora Rovic; Mouna El Bakkali; Brian Bradshaw; Eszter Posfai; Fredrik Lanner; Fredrik Lanner; Irene Talon; Sophie Petropoulos; Sophie Petropoulos; Sophie Petropoulos; Janet Rossant; San Kit To;

evaluating totipotency using criteria of increasing stringency

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in vitro remains incompletely understood. Defining totipotency relies on a variety of assays of variable stringency. Here, we describe criteria to define totipotency. We explain how distinct criteria of increasing stringency can be used to judge totipotency by evaluating candidate totipotent cell types in mice, including early blastomeres and expanded or extended pluripotent stem cells. Our data challenge the notion that expanded or extended pluripotent states harbour increased totipotent potential relative to conventional embryonic stem cells under in vitro and in vivo conditions.

Related Organizations United States

Male, Pluripotent Stem Cells, Blastomeres, Gene Expression Profiling, Cell Differentiation, Embryo, Mammalian, Mice, Animals, Cell Lineage, Female, Gene Regulatory Networks, Single-Cell Analysis, Totipotent Stem Cells, Embryonic Stem Cells